P-selectin glycoprotein ligand 1 promotes T cell lymphoma development and dissemination

P-selectin glycoprotein ligand-1 negatively regulates T-cell immune responses.

Cell surface sialomucins often act as antiadhesive molecules by virtue of their extended structure and negative charge. CD43 is one such sialomucin, expressed on most leukocytes. P-selectin glycoprotein ligand-1 (PSGL-1) is another sialomucin expressed by leukocytes. It serves as a major selectin ligand, but no antiadhesive role for it has been described. In this study, we showed that PSGL-1-de...

P-selectin glycoprotein ligand-1 (PSGL-1) is a ligand for L-selectin in neutrophil aggregation.

In inflammation, activated neutrophils adhere to endothelial cells and aggregate with one another. While beta 2-integrin and L-selectin are essential for aggregation, their ligands remain to be identified. We have previously shown that L-selectin mediates a carbohydrate-dependent interaction in aggregation (Simon et al: J Immunol 149:2765, 1992; Rochon et al: J Immunol 152:1385, 1994). We have ...

Dimerization of P-Selectin Glycoprotein Ligand-1 (PSGL-1) Required for Optimal Recognition of P-Selectin

Interactions between P-selectin, expressed on endothelial cells and activated platelets, and its leukocyte ligand, a homodimer termed P-selectin glycoprotein ligand-1 (PSGL-1), mediate the earliest adhesive events during an inflammatory response. To investigate whether dimerization of PSGL-1 is essential for functional interactions with P-selectin, a mutant form of PSGL-1 was generated in which...

Inflamed Skin E-Selectin-Dependent T Cell Migration into Glycoprotein Ligand-1 to Mediate CD43 Collaborates with P-Selectin

Two by two: the pairings of P-selectin and P-selectin glycoprotein ligand 1.

T of circulating leukocytes to specific areas of microbial invasion or tissue injury is critical for host defense and wound repair. If it is defective, syndromes of cellular immune deficiency result; conversely, if targeting is uncontrolled or dysregulated, accumulation of leukocytes may cause inflammatory tissue damage (1–3). In this issue of PNAS, Ramachandran and coworkers (4) report new asp...